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What XTANDI is used for

XTANDI contains enzalutamide, an androgen receptor inhibitor medicine, which is used to treat adult men with prostate cancer that has spread to other parts of the body after they have received previous treatment with docetaxel.

This medicine works by blocking the activity of hormones called androgens (such as testosterone). By blocking androgens, XTANDI stops prostate cancer cells from growing and dividing.

Ask your doctor if you have any questions about why this medicine has been prescribed for you.Your doctor may have prescribed it for another reason.

XTANDI is not for use in children and adolescents.

Before you take XTANDI

When you must not take it

Do not take XTANDI if you have an allergy to:

  • any medicine containing enzalutamide
  • any of the ingredients listed at the end of this leaflet.

Some of the symptoms of an allergic reaction may include:

  • shortness of breath
  • wheezing or difficulty breathing
  • swelling of the face, lips, tongue or other parts of the body
  • rash, itching or hives on the skin.

Do not take XTANDI if you are pregnant or may become pregnant.

Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.

If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you start to take it

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.

Tell your doctor if you:

  • have a history of seizures
  • have had a serious head injury or a history of head trauma
  • have had a stroke
  • have had brain tumors, or cancer which has spread to the brain
  • drink very large amounts of alcohol either regularly or from time to time
  • are taking a medicine that can cause seizures or that increase risks for having seizures (see Taking other medicines)

In some of these situations you have may a higher risk of seizures.

Tell your doctor if you have:

  • heart or blood pressure problems
  • kidney problems
  • liver problems
  • a partner who is pregnant or plans to become pregnant. Men who are sexually active with a pregnant woman must use a condom during and for 3 months after treatment with XTANDI. If their sexual partner may become pregnant, a condom and another form of birth control must be used during and for 3 months after treatment. Talk with your doctor if you have questions about birth control. Your doctor can discuss with you the risks and benefits involved.

If you have not told your doctor about any of the above, tell him/her before you start taking XTANDI.

Taking other medicines

Tell your doctor if you are taking any of the following medicines.

When taken at the same time as XTANDI, these medicines may increase the risk of a seizure:

  • certain medicines used to treat asthma and other respiratory diseases (e.g. aminophylline, theophylline)
  • medicines used to treat certain psychiatric disorders such as depression and schizophrenia (e.g. clozapine, olanzapine, risperidone, ziprasidone, bupropion, lithium, chlorpromazine, thioridazine, amitriptyline, desipramine, doxepin, imipramine, mirtazapine)
  • certain medicines for the treatment of pain (e.g. pethidine)

Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and XTANDI may interfere with each other. These include certain medicines used to:

  • treat pain (e.g. fentanyl, tramadol, paracetamol)
  • thin the blood, or to prevent blood clots (e.g. warfarin)
  • lower cholesterol (e.g. gemfibrozil, atorvastatin, simvastatin)
  • treat cancer (e.g. cabazitaxel)
  • treat epilepsy (e.g. carbamazepine, clonazepam, phenytoin, primidone, valproic acid)
  • treat certain psychiatric disorders such as severe anxiety or schizophrenia (e.g. diazepam, midazolam, haloperidol)
  • treat sleep disorders (e.g. zolpidem)
  • treat heart conditions or lower blood pressure (e.g. bisoprolol, digoxin, diltiazem, felodipine, nicardipine, nifedipine, propanolol, verapamil)
  • treat serious disease related to inflammation (e.g. dexamethasone, prednisolone)
  • treat HIV infection (e.g. indinavir, ritonavir)
  • treat bacterial infections (e.g. clarithromycin, doxycycline, rifampicin)
  • treat thyroid disorders (e.g. levothyroxine)
  • treat gout (e.g. colchicine)
  • prevent heart conditions or strokes (dabigatran etexilate).

These medicines may be affected by XTANDI or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.

How to take XTANDI

Follow directions given to you by your doctor or pharmacist carefully.

If you do not understand the instructions on the box, ask your doctor or pharmacist for help.

How much to take

The usual dose is four 40 mg capsules taken at the same time once a day. Your doctor may reduce your dose depending on your medical conditions.

Reduced dose:
If you are taking a reduced dose of XTANDI, you may use the remaining capsules in the open dose compartment for your next scheduled dose, provided that the capsules have been otherwise stored under the conditions described below (see After Taking XTANDI, Storage).

How to take it

Swallow the capsules whole with a full glass of water. Do not chew, dissolve or open the capsule before swallowing.

You can take the capsule with or without food.

When to take it

Take your medicine at about the same time each day. Taking it at the same time each day will help you remember when to take it.

How long to take it

Continue taking your medicine for as long as your doctor tells you. Do not stop treatment with XTANDI unless your doctor tells you to.

If you forget to take it

Take it as soon as you remember, and then go back to taking your medicine as you would normally.

If you forget to take XTANDI for the whole day, take your usual dose the following day.

If you forget to take XTANDI for more than one day, talk to your doctor immediately.

Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.

If you are not sure what to do, ask your doctor or pharmacist.

If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much XTANDI. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

While you are taking XTANDI

Things you must do

If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking XTANDI.

Tell any other doctors, dentists, and pharmacists who treat you that you are taking this medicine.

If you become pregnant while taking this medicine, tell your doctor immediately.

Things you must not do

Do not take XTANDI to treat any other complaints unless your doctor tells you to.

Do not give your medicine to anyone else, even if they have the same condition as you.

Do not stop taking your medicine or alter the dosage without checking with your doctor.

Do not drive or operate machinery until you know how XTANDI affects you.

XTANDI may have a moderate effect on your ability to drive or use any tools or machines as the side effects for XTANDI include seizures.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking XTANDI. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

Do not be alarmed by the following lists of side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist immediately if you have a seizure.

Seizures are more likely if you take more than the recommended dose of this medicine, if you take some other medicines, or if you are at higher than usual risk of seizures. If you have a seizure during treatment, stop taking XTANDI and see your doctor as soon as possible.

Tell your doctor or pharmacist if you notice any of the following:

  • headache
  • hot flushes
  • falls
  • broken bones
  • hallucinations
  • feeling anxious
  • dry skin
  • itching
  • high blood pressure
  • difficulty remembering
  • difficulty thinking clearly
  • forgetfulness
  • reduced concentration.

Tell your doctor or pharmacist if you notice anything that is making you feel unwell. Other side effects not listed above may also occur in some people.

Some of these side effects (for example, changes in blood test results or blood pressure) can only be found when your doctor does tests from time to time to check your progress.

After taking XTANDI


Keep your capsules in the pack until it is time to take them. If you take the capsules out of the pack they may not keep well.

If you are taking a reduced dose of XTANDI, you may store the remaining capsules in the open dose compartment until the next dose, provided that the capsules have been otherwise stored under the conditions described below.

Keep your capsules in the original packaging in a cool dry place where the temperature stays below 25°C.

Do not store XTANDI or any other medicine in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.

Do not take any capsule that is leaking, damaged, or shows signs of tampering.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Do not take this medicine after the expiry date which is stated on the cardboard wallet and outer carton. The expiry date refers to the last day of that month.


If your doctor tells you to stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

Do not throw away any medicines via wastewater or household waste.

Product description

What it looks like

XTANDI capsules are white to off-white, oblong soft capsules with "ENZ" written on one side.

XTANDI is available in packs of 112 capsules (in 4 wallets of 28 capsules).


XTANDI contains 40 mg of enzalutamide as the active ingredient.

Each capsule also contains:

  • caprylocaproyl macrogolglycerides
  • butylated hydroxyanisole
  • butylated hydroxytoluene
  • gelatin
  • sorbitol
  • sorbitan
  • glycerol
  • titanium dioxide
  • purified water
  • black iron oxide
  • polyvinyl acetate phthalate

Note: This information may not be actual at the time of reading. Always look for actual instructions in the package with the medication.
It is forbidden to use these materials without the advice of healthcare professional.

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